Article

ATP citrate lyase is an essential player of the metabolic rewiring induced by PTEN loss during T-ALL development

2023-03-27

Abstract excerpt

<h4>Summary</h4> Alterations inactivating the tumor suppressor gene PTEN drive the development of solid and hematological cancers, such as T-cell acute lymphoblastic leukemia (T-ALL), whereby PTEN loss defines poor-prognosis patients. We investigated the metabolic rewiring induced by PTEN loss in T-ALL, aiming at identifying novel metabolic vulnerabilities. We showed that the enzyme ATP citrate lyase (ACLY) is s...

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Literature Corpus work: 1042bbdb-6564-5e66-9538-622bca931501
DOI: 10.1101/2023.03.27.534353

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