Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

2 Aug 2021

Abstract excerpt

Despite progress in the treatment of acute lymphoblastic leukemia (ALL), T-cell ALL (T-ALL) has limited treatment options, particularly in the setting of relapsed/refractory disease. Using an unbiased genome-scale CRISPR-Cas9 screen we sought to identify pathway dependencies for T-ALL which could be harnessed for therapy development. Disruption of the one-carbon folate, purine and pyrimidine pathways scored as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Biochemical and Molecular Research
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34341479
DOI: 10.1038/s41375-021-01361-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapyPMID 34341479Read ↗

A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the SpotlightSemantic proximity Read ↗

Multifaceted role of serine hydroxymethyltransferase in health and diseaseSemantic proximity Read ↗

The Taurine-TauT Axis in Hematologic Malignancies: A Review on Redox Homeostasis, Mitochondrial tRNA Stabilization, Leukemic Stem Cell Persistence, and Therapeutic VulnerabilitiesSemantic proximity Read ↗

MondoA Drives Malignancy in cALL through Enhanced Adaptation to Metabolic StressSemantic proximity Read ↗

Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable VulnerabilitySemantic proximity Read ↗

Drivers of de novo Serine/Glycine synthesis in acute leukemia.Semantic proximity Read ↗

Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs.Semantic proximity Read ↗

Genome-wide CRISPR/Cas9 screening identifies determinant of panobinostat sensitivity in acute lymphoblastic leukemiaSemantic proximity Read ↗

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistanceSemantic proximity Read ↗

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.Semantic proximity Read ↗

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid LeukemiaSemantic proximity Read ↗

Defective Nucleotide Catabolism Defines a Subset of Cancers Sensitive to Purine Nucleoside Phosphorylase InhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.