Article

IMPDH inhibitors for anti-tumor therapy in tuberous sclerosis complex

2019-11-11

Abstract excerpt

<h4>Structured Abstract</h4> <h4>Purpose</h4> mTORC1 is a master regulator of anabolic cell growth and proliferation that is activated in the majority of human tumors. We recently demonstrated that elevated mTORC1 activity in cells and tumors can confer dependence on IMPDH, the rate-limiting enzyme in de novo guanylate nucleotide synthesis, to support increased ribosome biogenesis and cell viability. Pharmacolo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db8c58e8-a482-5c08-bdac-a06622aaf225
DOI: 10.1101/835199

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IMPDH inhibitors for anti-tumor therapy in tuberous sclerosis complexDOI 10.1101/835199Read

PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemiaSemantic proximity Read

Paradigm shift in the treatment of tuberous sclerosis: Effectiveness of everolimusSemantic proximity Read

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatmentSemantic proximity Read

mTOR inhibitors in the pharmacologic management of tuberous sclerosis complex and their potential role in other rare neurodevelopmental disordersSemantic proximity Read

Recent Advances and Challenges of mTOR Inhibitors Use in the Treatment of Patients with Tuberous Sclerosis ComplexSemantic proximity Read

Perfect match: mTOR inhibitors and tuberous sclerosis complexSemantic proximity Read

Therapeutic Approaches to Tuberous Sclerosis Complex: From Available Therapies to Promising Drug TargetsSemantic proximity Read

Tuberous sclerosis complex.Semantic proximity Read

Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complexSemantic proximity Read

Epstein-Barr Virus Latent Membrane Protein 1 Subverts IMPDH pathways to drive B-cell oncometabolismSemantic proximity Read

Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapySemantic proximity Read

mTOR Inhibitors in Tuberous Sclerosis ComplexSemantic proximity Read