Article

SIEVEseq: One-stop differential expression, variability, and skewness analyses using RNA-Seq data

2024-04-13

Abstract excerpt

RNA-Seq data analysis is commonly biased towards detecting differentially expressed genes and insufficiently conveys the complexity of gene expression changes between biological conditions. This bias arises because discrete count models cannot fully and independently parameterize the mean, variance, and skewness of gene expression distributions. Therefore, a unified statistical framework that simultaneously tests...

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Literature Corpus work: 3320c09e-1363-573c-b77a-d8fef2b1ecef
DOI: 10.1101/2024.04.09.588804

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