Article

AWmeta empowers adaptively-weighted transcriptomic meta-analysis

2025-05-07

Abstract excerpt

Transcriptomic meta-analysis enhances biological veracity and reproducibility by integrating diverse studies, yet prevailing P -value or effect-size integration approaches exhibit limited power to resolve subtle signatures. We present AWmeta, an adaptively-weighted framework that unifies both paradigms. Benchmarking across 35 Parkinson’s and Crohn’s disease datasets spanning diverse tissues and adaptively down-we...

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Literature Corpus work: d731e3c9-bc0c-5af9-8499-f8e43df00c17
DOI: 10.1101/2025.05.06.650408

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