Article

Cell type-aware analysis of RNA-seq data

2020-07-14

Abstract excerpt

Most tissue samples are composed of different cell types. Differential expression analysis without accounting for cell type composition cannot separate the changes due to cell type composition or cell type-specific expression. We propose a computational framework to address these limitations: C ell Type A ware analysis of R NA- seq (CARseq). CARseq employs a negative binomial distribution that appropriately mo...

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Literature Corpus work: 72050e9f-27da-51ae-adaf-b1b7df321fdf
DOI: 10.1101/2020.07.13.201061

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