Article

clrDV: A differential variability test for RNA-Seq data based on the skew-normal distribution

2022-09-27

Abstract excerpt

<h4>Summary</h4> Genes that show differential variability between conditions are important for complementing a systems biology understanding of the molecular players involved in a biological process. Under the dominant paradigm for modeling RNA-Seq gene counts using the negative binomial model, tests of differential variability are challenging to develop, owing to dependence of the variance on the mean. The limit...

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Literature Corpus work: 84e5e1e1-ed75-55c6-8301-1f6e46bd4aca
DOI: 10.1101/2022.09.25.508885

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