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Design and Molecular Simulation of a Rituximab-Methimazole Hybrid Compound for Selective Thyroid-Stimulating Hormone Receptor Inhibition in Graves’ Disease

2025-07-22

Abstract excerpt

<h4>Introduction: </h4> Graves' disease (GD), an autoimmune disorder characterized by hyperthyroidism and the production of autoantibodies targeting the thyroid-stimulating hormone receptor (TSHR), poses a considerable challenge in clinical management. Antithyroid medications block thyroid hormone synthesis and are usually the first-line treatment. In recent years, the advent of computational compound design has o...

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Literature Corpus work
331928d5-5429-5ff0-a883-8cb62de8e8bd
DOI
10.1590/scielopreprints.12615
Open publication

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