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Rational Design and Molecular Docking Studies of Novel Dual-Thionamide Antithyroid Agent with Enhanced Thyroid Peroxidase Inhibition Through Bidentate Heme Coordination

2025-10-14

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold>Hyperthyroidism management remains constrained by limited pharmacological innovation, with thionamide therapy exhibiting suboptimal remission rates and significant adverse effects. Thyroid peroxidase (TPO) inhibition through conventional monodentate heme coordination demonstrates transient efficacy, necessitating novel therapeutic approaches. <bold>Objective:</bo...

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Literature Corpus work
a8ebfa64-0b83-59ee-8120-2be5f0104d45
DOI
10.21203/rs.3.rs-7830056/v1
Open publication

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