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Computational Identification of SSTR2 Ligands as Potential Therapeutics for High-Risk Neuroblastoma Stage 4: A Multi-Platform In Silico and Molecular Dynamics Study

2026-08-10

Abstract excerpt

Somatostatin receptor subtype 2 (SSTR2) is overexpressed in high-risk neuroblastoma stage 4 (NBS4) in patients with chromosome 17q gain, making it a potential therapeutic target. This computational study employed a multi-platform drug design workflow to identify novel SSTR2 ligands based on the selective agonist L-054,522. Using BROOD (OpenEye Scientific), 5,507 structural analogues were generated, from which 293...

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Literature Corpus work
4cd71845-eb60-5183-a4aa-93a3c2793221
DOI
10.20944/preprints202606.1249.v4
Open publication

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