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AI-Driven Structural Mapping of Thyroid Autoantigens Reveals High-Confidence Conformational Epitopes for Precision Immunotherapy

2025-11-10

Abstract excerpt

<title>Abstract</title> <p> <bold>Introduction:</bold> Autoimmune thyroid diseases (AITD) are the most common organ-specific autoimmune disorders, driven by loss of immune tolerance to thyroid peroxidase (TPO), thyroglobulin (Tg), and thyrotropin receptor (TSHR). Understanding the three-dimensional (3D) architecture of these autoantigens is essential for the rational design of antigen-specific immunotherapies t...

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Literature Corpus work
36f00251-078e-5634-88ad-1ce1db54c357
DOI
10.21203/rs.3.rs-8059011/v1
Open publication

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AI-Driven Structural Mapping of Thyroid Autoantigens Reveals High-Confidence Conformational Epitopes for Precision ImmunotherapyDOI 10.21203/rs.3.rs-8059011/v1
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