Article
Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus.
The Journal of cell biology - 2 Dec 2019
Fu Gang, Zhao Lei, Dymek Erin, Hou Yuqing, Song Kangkang, Phan Nhan, Shang Zhiguo, Smith Elizabeth F, Witman George B, Nicastro Daniela
Abstract excerpt
Nearly all motile cilia contain a central apparatus (CA) composed of two connected singlet microtubules with attached projections that play crucial roles in regulating ciliary motility. Defects in CA assembly usually result in motility-impaired or paralyzed cilia, which in humans causes disease. Despite their importance, the protein composition and functions of the CA projections are largely unknown. Here, we...
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