Article

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

2024-03-21

Abstract excerpt

<h4>Summary</h4> Motile cilia have essential cellular functions in development, reproduction, and homeostasis. Genetic causes for motile ciliopathies have been identified, but the consequences on cellular functions beyond impaired motility remain unknown. Variants in CCDC39 and CCDC40 cause severe disease not explained by loss of motility. Using human cells with pathological variants in these genes, Chlamydomo...

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Literature Corpus work: 866f2c9a-fbdd-5f67-b994-53dc57409adf
DOI: 10.1101/2024.03.20.585965

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