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Article

Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice.

Circulation research - 1 Aug 2014

Calkin Anna C, Lee Stephen D, Kim Jason, Van Stijn Caroline M W, Wu Xiao-Hui, Lusis Aldons J, Hong Cynthia, Tangirala Rajendra I, Tontonoz Peter

Abstract excerpt

RATIONALE: The E3 ubiquitin ligase inducible degrader of the low-density lipoprotein receptor (IDOL) triggers lysosomal degradation of the low-density lipoprotein receptor. The tissue-specific effects of the IDOL pathway on plasma cholesterol and atherosclerosis have not been examined. OBJECTIVE: Given that the liver is the primary determinant of plasma cholesterol levels, we sought to examine the consequence of...

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Source

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Identifiers

PMID: 24935961
DOI: 10.1161/CIRCRESAHA.115.304440
PMCID: PMC4119488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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