ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.

doi:10.1016/j.atherosclerosis.2015.12.002

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Article

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.

Atherosclerosis - 1 Feb 2016

Niimi Manabu, Yang Dongshan, Kitajima Shuji, Ning Bo, Wang Chuan, Li Shen, Liu Enqi, Zhang Jifeng, Eugene Chen Y, Fan Jianglin

Abstract excerpt

OBJECTIVE: Rabbits are one of the best animal models for the study of hyperlipidemia and atherosclerosis. Although many transgenic rabbits have been created, the development of gene knockout (KO) rabbits has been impossible due to the lack of rabbit embryonic stem cells. We along with others recently generated KO rabbits using genome editing techniques. In the current study, we characterized the lipoprotein...

Topics

Animals
Apolipoproteins E
Disease Models, Animal
Electrophoresis, Agar Gel
Genetic Predisposition to Disease
Humans
Hyperlipidemias
Immunoblotting
Male
Rabbits

Source

Open in PubMed

Identifiers

PMID: 26724529
DOI: 10.1016/j.atherosclerosis.2015.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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