Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.

Molecular and cellular biology - 1 May 2011

Scotti Elena, Hong Cynthia, Yoshinaga Yuko, Tu Yiping, Hu Yan, Zelcer Noam, Boyadjian Rima, de Jong Pieter J, Young Stephen G, Fong Loren G, Tontonoz Peter

Abstract excerpt

Previously, we identified the E3 ubiquitin ligase Idol (inducible degrader of the low-density lipoprotein [LDL] receptor [LDLR]) as a posttranscriptional regulator of the LDLR pathway. Idol stimulates LDLR degradation through ubiquitination of its C-terminal domain, thereby limiting cholesterol uptake. Here we report the generation and characterization of mouse embryonic stem cells homozygous for a null mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Stem Cells
Share to Lipoproteins, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver X Receptors

Share to Orphan Nuclear Receptors

Share to Proprotein Convertase 9

Share to Proprotein Convertases

Share to Receptors, LDL

Share to Sterols

Source

Open in PubMed Open full text

Identifiers

PMID: 21343340
DOI: 10.1128/MCB.01469-10
PMCID: PMC3133228

Genes

LDLR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.PMID 21343340Read ↗

Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptorSemantic proximity Read ↗

Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice.Semantic proximity Read ↗

Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL).Semantic proximity Read ↗

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.Semantic proximity Read ↗

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbitsSemantic proximity Read ↗

Suppression of Idol expression is an additional mechanism underlying statin-induced up-regulation of hepatic LDL receptor expressionSemantic proximity Read ↗

Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.Semantic proximity Read ↗

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.Semantic proximity Read ↗

Ubiquitin E3 ligase mediated regulation of HMG-CoA ReductaseSemantic proximity Read ↗

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.Semantic proximity Read ↗

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Semantic proximity Read ↗

Dynamin is involved in endolysosomal cholesterol delivery to the endoplasmic reticulum: role in cholesterol homeostasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.