Article

Human ERG Oncoprotein Represses <i>Chip/LDB1</i> LIM-Domain Binding Gene in <i>Drosophila</i>

2022-06-05

Abstract excerpt

ERG oncoprotein, a master transcription factor, targets diverse arrays of genes in different cancers. Identifying oncogenically relevant ones from these ERG targets, however, is challenging. Here we show that heterologous ERG disrupts a LIM-homeodomain (LIM-HD) complex, Chip-Tailup, in Drosophila . In the posterior thorax (notum) primordium, ERG-induced upregulation of E(z)/EZH2 trimethylates histones in Chip p...

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Literature Corpus work: 4359b07b-c166-54e2-8958-407548c943a5
DOI: 10.1101/2022.06.05.494862

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