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Article

Essential requirement for RING finger E3 ubiquitin ligase Hakai in early embryonic development of Drosophila.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2009

Kaido Masako, Wada Housei, Shindo Masayo, Hayashi Shigeo

Abstract excerpt

Hakai is a RING finger type E3 ubiquitin ligase that is highly conserved in metazoans. Mammalian Hakai was shown to bind and ubiquitinate the intracellular domain of E-cadherin, and this activity is implicated in down-regulation of E-cadherin during v-Src-induced cellular transformation. To evaluate this model in vivo, we studied the function of the Drosophila homologue of Hakai. In cultured S2 cells, Drosophila...

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Identifiers

PMID: 19682089
DOI: 10.1111/j.1365-2443.2009.01335.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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