Article

Fine-tuning Polygenic Risk Scores with GWAS Summary Statistics

2019-10-18

Abstract excerpt

Polygenic risk scores (PRSs) have wide applications in human genetics research. Notably, most PRS models include tuning parameters which improve predictive performance when properly selected. However, existing model-tuning methods require individual-level genetic data as the training dataset or as a validation dataset independent from both training and testing samples. These data rarely exist in practice, creating...

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Literature Corpus work: 90c270f9-d05c-5b6a-bb06-e8a98ac53183
DOI: 10.1101/810713

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