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Article

Tuning parameters for polygenic risk score methods using GWAS summary statistics from training data.

Nature communications - 2 Jan 2024

Jiang Wei, Chen Ling, Girgenti Matthew J, Zhao Hongyu

Abstract excerpt

Various polygenic risk scores (PRS) methods have been proposed to combine the estimated effects of single nucleotide polymorphisms (SNPs) to predict genetic risks for common diseases, using data collected from genome-wide association studies (GWAS). Some methods require external individual-level GWAS dataset for parameter tuning, posing privacy and security-related concerns. Leaving out partial data for parameter...

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Identifiers

PMID: 38169469
DOI: 10.1038/s41467-023-44009-0
PMCID: PMC10762162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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