Article

The genetic dissection of fetal haemoglobin persistence in sickle cell disease in Nigeria

2023-05-18

Abstract excerpt

<h4>Background</h4> The clinical severity of sickle cell disease (SCD) is strongly influenced by the level of fetal haemoglobin (HbF) persistent in each patient. Three major HbF loci ( BCL11A , HBS1L-MYB , and Xmn1-HBG2 ) have been reported, but a considerable hidden heritability remains. <h4>Aim</h4> Building on the power of a large and genetically diverse patient pool present in Nigeria, we conducted a genome-wi...

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Literature Corpus work: 32a12a36-07bd-5be9-aded-1e0068b79644
DOI: 10.1101/2023.05.16.23289851

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