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Article

A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia.

PloS one - 1 Jan 2018

Adeyemo Titilope A, Ojewunmi Oyesola O, Oyetunji Idat A, Rooks Helen, Rees David C, Akinsulie Adebola O, Akanmu Alani S, Thein Swee Lay, Menzel Stephan

Abstract excerpt

Genetic variants at three quantitative trait loci (QTL) for fetal haemoglobin (HbF), BCL11A, HBS1L-MYB and the β-globin gene cluster, have attracted interest as potential targets of therapeutic strategies for HbF reactivation in sickle cell anaemia (SCA). We carried out the first systematic evaluation of critical single nucleotide polymorphisms at these disease modifier loci in Nigerian patients with SCA. Common...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29879141
DOI: 10.1371/journal.pone.0197927
PMCID: PMC5991720

Genes

MYB
HBG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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