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Article

Functional polymorphisms of BCL11A and HBS1L-MYB genes affect both fetal hemoglobin level and clinical outcomes in a cohort of children with sickle cell anemia.

Annals of hematology - 1 Jul 2020

Sales Rahyssa Rodrigues, Belisário André Rolim, Faria Gabriela, Mendes Fabiola, Luizon Marcelo Rizzatti, Viana Marcos Borato

Abstract excerpt

Fetal hemoglobin (HbF) ameliorates clinical severity of sickle cell anemia (SCA). The major loci regulating HbF levels are HBB cluster, BCL11A, and HMIP-2 (HBS1L-MYB). However, the impact of noncoding single-nucleotide polymorphisms (SNPs) in these loci on clinical outcomes and their functional role on regulating HbF levels should be better elucidated. Therefore, we performed comprehensive association analyses of...

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PMID: 32447424
DOI: 10.1007/s00277-020-04079-2

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