Article
Genetic architecture of hemoglobin F control
1 May 2009
Abstract excerpt
Purpose of review Much effort has been spent on understanding the regulation of fetal hemoglobin (HbF, α2γ2) production and its reactivation in adults, as elevated HbF levels are correlated with reduced morbidity and mortality in sickle cell anemia and β thalassemia, diseases that represent a major public health problem. Interindividual HbF variation is largely genetically controlled, but the inheritance patterns...
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