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Article

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer.

BMC medical genetics - 10 Feb 2015

Mtatiro Siana N, Mgaya Josephine, Singh Tarjinder, Mariki Harvest, Rooks Helen, Soka Deogratius, Mmbando Bruno, Thein Swee Lay, Barrett Jeffrey C, Makani Julie, Cox Sharon E, Menzel Stephan

Abstract excerpt

BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals, high HbF levels have major clinical benefits in patients with sickle cell disease (SCD) or β thalassemia. Here, we present our detailed investigation of...

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Share to Anemia, Sickle Cell
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Conserved Sequence

Share to Enhancer Elements, Genetic

Share to Fetal Hemoglobin

Share to Proto-Oncogene Proteins c-myb

Share to Quantitative Trait Loci

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Source

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Identifiers

PMID: 25928412
DOI: 10.1186/s12881-015-0148-3
PMCID: PMC4422446

Genes

MYB
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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