Article

<i>In vitro</i> evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding

2021-12-25

Abstract excerpt

Emerging SARS CoV-2 variants are creating major challenges in the ongoing Covid-19 pandemic. Predicting CoV-2 mutations that increase transmissibility or immune evasion would be extremely valuable in development of broad-acting therapeutics and vaccines and prioritising viral monitoring and containment. Using in vitro evolution, we identify a double mutation in CoV-2 receptor binding domain (RBD) that increases a...

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Literature Corpus work: d1ae50ac-9c48-552e-a619-761f60ccd7b2
DOI: 10.1101/2021.12.23.473975

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