Article

Macrophages facilitate interclonal cooperation-induced tumor heterogeneity and malignancy by activating the innate immune signaling

2024-06-30

Abstract excerpt

Tumor heterogeneity is a common hallmark of cancer and is considered a major cause of treatment failure and relapse, yet it remains poorly understood how various types of cells communicate within the tumor microenvironment (TME) to regulate tumor progression in vivo . Here we establish a tumor heterogeneity model in Drosophila eye epithelium by mutating the tricellular junction protein M6 in cells surrounding...

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Literature Corpus work: a1a4d54e-c688-582d-9140-7d17c164c733
DOI: 10.1101/2024.06.27.600955

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