Article
Structural basis for the reaction cycle and transport mechanism of human Na+-sulfate cotransporter NaS1 (SLC13A1).
Science advances - 22 Nov 2024
Chen Xudong, Zhang Youqi, Yin Jian, Liu Chang, Xie Min, Wang Yixue, Chen Meiying, Zhang Rui, Yuan Xinyi, Li De, Chen Xiangmei, Gao Xin, Cai Guangyan, Zhang Sensen, Zhou Boda, Yang Maojun
Abstract excerpt
Sulfate (SO42-) is a pivotal inorganic anion with essential roles in mammalian physiology. NaS1, a member of solute carrier 13 family and divalent anion/sodium symporter family, functions as a Na+-sulfate cotransporter, facilitating sulfate (re)absorption across renal proximal tubule and small intestine epithelia. While previous studies have linked several human disorders to mutations in the NaS1 gene, its...
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