Article

Hypernatremia Enhances Transient Outward Potassium and Late Sodium Currents in a Mouse Model of Long QT Syndrome Type 3

2025-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac voltage-gated sodium channel gain-of-function (Na v GOF) is characterized by action potential duration (APD) prolongation. Hypernatremia and perinexal widening synergistically prolong cardiac APD in guinea pig. However, guinea pig lack the transient outward potassium current (I to ), which could be increased by hypernatremia and thereby shorten APD. <h4>Objective</h4> Determine wheth...

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Literature Corpus work: 326411c4-79fe-5e58-a77e-4a9e6f5ba147
DOI: 10.64898/2025.12.04.692461

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