Article
A null mutation of the neuronal sodium channel NaV1.6 disrupts action potential propagation and excitation-contraction coupling in the mouse heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2012
Noujaim Sami F, Kaur Kuljeet, Milstein Michelle, Jones Julie M, Furspan Philip, Jiang Daniel, Auerbach David S, Herron Todd, Meisler Miriam H, Jalife José
Abstract excerpt
Evidence supports the expression of brain-type sodium channels in the heart. Their functional role, however, remains controversial. We used global Na(V)1.6-null mice to test the hypothesis that Na(V)1.6 contributes to the maintenance of propagation in the myocardium and to excitation-contraction (EC) coupling. We demonstrated expression of transcripts encoding full-length Na(V)1.6 in isolated ventricular myocytes...
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