Article

Electrophysiological properties of mouse and epitope-tagged human cardiac sodium channel Nav1.5 expressed in HEK293 cells

2013-04-05

Abstract excerpt

<h4>Background: </h4> The pore-forming subunit of the cardiac sodium channel, Na v 1.5, has been previously found to be mutated in genetically determined arrhythmias. Na v 1.5 associates with many proteins that regulate its function and cellular localisation. In order to identify more in situ Na v 1.5 interacting proteins, genetically-modified mice with a high-affinity epitope in the sequence of Na v 1.5 can...

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Literature Corpus work: 5fda1d5a-f6fe-5afe-acf3-32757d8b505c
DOI: 10.12688/f1000research.2-48.v2

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