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Article

Divergent action potential morphologies reveal nonequilibrium properties of human cardiac Na channels.

Cardiovascular research - 1 Dec 2004

Magyar János, Kiper Carmen E, Dumaine Robert, Burgess Don E, Bányász Tamás, Satin Jonathan

Abstract excerpt

OBJECTIVE: Fast inward Na current (I(Na)) carried by the voltage-gated Na channel (Na(V)1.5) is critical for action potential (AP) propagation and the rapid upstroke of the cardiac AP. In addition, a small fraction of Na(V)1.5 channels remains open throughout the plateau of the AP, and this current is termed as late I(Na). In patients with mutant Na(V)1.5-based congenital long Q-T (LQT) syndrome, mutant channels...

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Identifiers

PMID: 15537501
DOI: 10.1016/j.cardiores.2004.07.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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