Article

Interferon Regulatory Factor 5 represses oxidative respiration in human and murine macrophages by inhibition of mitochondrial matrix protein GHITM

2021-05-06

Abstract excerpt

<title>Abstract</title> <p>Over the course of diet-induced obesity (DIO), adipose tissue macrophage (ATM) populations transition from highly oxidative and protective to highly inflammatory and metabolically deleterious. Here, we demonstrate that the Interferon Regulatory Factor (IRF)-5 is a key molecular switch mediating repression of macrophage oxidative capacity early in DIO. ATMs from mice with a myeloid-speci...

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Literature Corpus work: 325e3432-8436-510d-8b5c-5d75a190ceb2
DOI: 10.21203/rs.3.rs-477956/v1

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