Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation.

Cells - 11 Nov 2019

Sindhu Sardar, Thomas Reeby, Kochumon Shihab, Wilson Ajit, Abu-Farha Mohamed, Bennakhi Abdullah, Al-Mulla Fahd, Ahmad Rasheed

Abstract excerpt

Interferon regulatory factor (IRF)-5 is known to be involved in M1 macrophage polarization, however, changes in the adipose expression of IRF5 in obesity and their relationship with the local expression of proinflammatory cytokines/chemokines are unknown. Therefore, IRF5 gene expression was determined in the subcutaneous adipose tissue samples from 53 non-diabetic individuals (6 lean, 18 overweight, and 29...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Body Weights and Measures

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Energy Metabolism

Share to Immunomodulation

Share to Inflammation

Share to Inflammation Mediators

Share to Interferon Regulatory Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 31718015
DOI: 10.3390/cells8111418
PMCID: PMC6912676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation.PMID 31718015Read ↗

Enhanced Adipose Expression of Interferon Regulatory Factor (IRF)-5 Associates with the Signatures of Metabolic Inflammation in Diabetic Obese PatientsSemantic proximity Read ↗

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.Semantic proximity Read ↗

Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodellingSemantic proximity Read ↗

Interferon Regulatory Factor 5 represses oxidative respiration in human and murine macrophages by inhibition of mitochondrial matrix protein GHITMSemantic proximity Read ↗

Toll-like receptor 5 in obesity: the role of gut microbiota and adipose tissue inflammation.Semantic proximity Read ↗

Putative positive role of inflammatory genes in fat deposition supported by altered gene expression in purified human adipocytes and preadipocytes from lean and obese adipose tissuesSemantic proximity Read ↗

Adipose Tissue Macrophage Phenotypes and Characteristics: The Key to Insulin Resistance in Obesity and Metabolic Disorders.Semantic proximity Read ↗

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.Semantic proximity Read ↗

The Emerging Role of Sfrp5 and Wnt5a in the Pathogenesis of Obesity: Implications for a Healthy Diet and LifestyleSemantic proximity Read ↗

Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice.Semantic proximity Read ↗

High-Fat Diet-Induced Dysregulation of Immune Cells Correlates with Macrophage Phenotypes and Chronic Inflammation in Adipose Tissue.Semantic proximity Read ↗

TREM-1 Associated Macrophage Polarization Plays a Significant Role in Inducing Insulin Resistance in the Obese PopulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.