Article

KIT-c-Jun Signaling Up-regulated HMGCS1 to Promote Colorectal Cancer Development

2022-04-19

Abstract excerpt

<h4>Purpose: </h4> Colorectal cancer (CRC) ranks 2nd in morbidity and 3rd in mortality among all cancers worldwide. 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) is ubiquitously expressed in humans. Remarkably, the mevalonate pathway is often dysregulated in many cancers, suggesting tumor dependency on this classic metabolic pathway. In addition to altered substrates in the mevalonate pathway, it was recently...

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Literature Corpus work: 325bf18c-6eff-5927-97e1-9752c84c72a9
DOI: 10.21203/rs.3.rs-1508182/v2

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