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Article

High expression of RUNX1 in colorectal cancer subtype accelerates malignancy by inhibiting HMGCR

4 Jul 2024

Abstract excerpt

Colorectal cancer (CRC) presents a complex landscape, characterized by both inter-tumor and intra-tumor heterogeneity. RUNX1, a gene implicated in modulating tumor cell growth, survival, and differentiation, remains incompletely understood regarding its impact on CRC prognosis. In our investigation, we discerned a positive correlation between elevated RUNX1 expression and aggressive phenotypes across various CRC...

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PMID: 38971271
DOI: 10.1016/j.phrs.2024.107293

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