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Article

The progression of HMGB1-induced autophagy in cancer biology

1 Dec 2018

Abstract excerpt

Autophagy is an important process of cellular degradation and has been proven to contribute to tumorigenesis. High-mobility group box 1 (HMGB1) is an abundant nonhistone protein that has been widely reported to play a central role in the induction of autophagy. In nucleus, HMGB1 upregulates the expression of HSP27 to induce autophagy. In cytoplasm, the Beclin-1/PI3K-III complex can be activated by HMGB1 to...

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PMID: 30643434
DOI: 10.2147/ott.s185876

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