Article
HMG-CoA synthase 1 is a synthetic lethal partner of BRAFV600E in human cancers.
The Journal of biological chemistry - 16 Jun 2017
Zhao Liang, Fan Jun, Xia Siyuan, Pan Yaozhu, Liu Shuangping, Qian Guoqing, Qian Zhiyu, Kang Hee-Bum, Arbiser Jack L, Pollack Brian P, Kudchadkar Ragini R, Lawson David H, Rossi Michael, Abdel-Wahab Omar, Merghoub Taha, Khoury Hanna J, Khuri Fadlo R, Boise Lawrence H, Lonial Sagar, Chen Fangping, Chen Jing, Lin Ruiting
Abstract excerpt
Contributions of metabolic changes to cancer development and maintenance have received increasing attention in recent years. Although many human cancers share similar metabolic alterations, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. Using an RNAi-based screen targeting the majority of the known metabolic proteins, we recently found that oncogenic...
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