Article

Targeting the TLK1-MK5 Axis Suppresses Prostate Cancer Metastasis

2025-03-04

Abstract excerpt

The spread of metastatic prostate cancer (PCa) is responsible for the majority of PCa-related deaths, yet the precise mechanisms driving this process remain unclear. We have identified a novel interaction between two distinct promotility factors, tousled-like kinase 1 (TLK1) and MAPK-activated protein kinase 5 (MK5), which triggers a signaling cascade that promotes metastasis. In PCa, the TLK1-MK5 pathway may play...

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Literature Corpus work: 32585ef8-bce5-58ff-ae6a-1486df6cb49c
DOI: 10.20944/preprints202503.0177.v1

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