Article

The TLK1-MK5 axis regulates motility, invasion, and metastasis of prostate cancer cells

2022-10-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Metastatic dissemination of prostate cancer (PCa) accounts for majority of PCa related deaths. However, the exact mechanism of PCa cell spread is still unknown. We uncovered a novel interaction between two unrelated promotility factors, tousled-like kinase 1 (TLK1) and MAPK-activated protein kinase 5 (MK5), which initiates a signaling cascade promoting metastasis. In PCa, TL...

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Literature Corpus work: 8e01ffbb-a720-5e78-abdd-756b0178ab46
DOI: 10.1101/2022.10.10.511643

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