Article

All-by-All Cytokine Receptor Pairing Network Unlocks Coding of Non-Natural T Cell States

2026-08-24

Abstract excerpt

Cytokine receptor pairing rules, set by evolution, confine JAK-STAT signaling to a narrow region of a far larger combinatorial space. Of more than 1,200 pairings theoretically possible among the ∼36 JAK-associated human cytokine receptors, only ∼30-40 exist in nature. Using a double-orthogonal platform, we enforced pairings across the full all-by-all receptor matrix and resolved a fine-grained STAT atlas richer th...

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Literature Corpus work: ec2e7d5b-9a3e-5e4c-831f-bd623857df5e
DOI: 10.64898/2026.08.19.745857

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