Article

The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approach

2017-11-13

Abstract excerpt

Genome instability is a characteristic of most cancers, contributing to the acquisition of genetic alterations that drive tumor progression. One important source of genome instability is linked to telomere dysfunction in cells with critically short telomeres that lack p53-mediated surveillance of genomic integrity. Here we research the probability that cancer emerges through an evolutionary pathway that includes a...

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Literature Corpus work: 3256706f-52ce-59a2-95aa-af7fd33624e4
DOI: 10.1101/218537

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