Genetic instability as a driver for immune surveillance

Abstract excerpt

Genetic instability is known to relate with carcinogenesis by providing tumors with a mechanism for fast adaptation. However, mounting evidence also indicates causal relation between genetic instability and improved cancer prognosis resulting from efficient immune response. Highly unstable tumors seem to accumulate mutational burdens that result in dynamical landscapes of neoantigen production, eventually inducing...

Topics

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• Antigens, Neoplasm
• Disease Susceptibility
• DNA Mismatch Repair
• Genomic Instability
• Immunologic Surveillance
• Models, Theoretical
• Mutation Rate
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

e572f147-25ca-55e2-845d-68dd2a072f5c

DOI

10.1101/527689