Stochastic tunneling and metastable states during the somatic evolution of cancer.

Abstract excerpt

Tumors initiate when a population of proliferating cells accumulates a certain number and type of genetic and/or epigenetic alterations. The population dynamics of such sequential acquisition of (epi)genetic alterations has been the topic of much investigation. The phenomenon of stochastic tunneling, where an intermediate mutant in a sequence does not reach fixation in a population before generating a double...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Clonal Evolution
• Share to Models, Genetic
• Share to Mutation