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Article

Evolutionary dynamics of tumor suppressor gene inactivation.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004

Nowak Martin A, Michor Franziska, Komarova Natalia L, Iwasa Yoh

Abstract excerpt

Tumor suppressor genes (TSGs) are important gatekeepers that protect against somatic evolution of cancer. Losing both alleles of a TSG in a single cell represents a step toward cancer. We study how the kinetics of TSG inactivation depends on the population size of cells and the mutation rates for the first and second hit. We calculate the probability as function of time that at least one cell has been generated...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15252197
DOI: 10.1073/pnas.0400747101
PMCID: PMC489986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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