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Article

The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling.

PloS one - 1 Jan 2013

Araujo Arturo, Baum Buzz, Bentley Peter

Abstract excerpt

Many cancers are aneuploid. However, the precise role that chromosomal instability plays in the development of cancer and in the response of tumours to treatment is still hotly debated. Here, to explore this question from a theoretical standpoint we have developed an agent-based model of tissue homeostasis in which to test the likely effects of whole chromosome mis-segregation during cancer development. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23991060
DOI: 10.1371/journal.pone.0072206
PMCID: PMC3753339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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