Article
Efficient simulation under a population genetics model of carcinogenesis.
Bioinformatics (Oxford, England) - 15 Mar 2011
Zhu Tianqi, Hu Yucheng, Ma Zhi-Ming, Zhang De-Xing, Li Tiejun, Yang Ziheng
Abstract excerpt
MOTIVATION: Cancer is well known to be the end result of somatic mutations that disrupt normal cell division. The number of such mutations that have to be accumulated in a cell before cancer develops depends on the type of cancer. The waiting time T(m) until the appearance of m mutations in a cell is thus an important quantity in population genetics models of carcinogenesis. Such models are often difficult to...
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