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Article

Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems.

Nature reviews. Cancer - 1 Jul 2015

Kashi Venkatesh P, Hatley Mark E, Galindo Rene L

Abstract excerpt

Rhabdomyosarcoma (RMS) is a mesenchymal malignancy composed of neoplastic primitive precursor cells that exhibit histological features of myogenic differentiation. Despite intensive conventional multimodal therapy, patients with high-risk RMS typically suffer from aggressive disease. The lack of directed therapies against RMS emphasizes the need to further uncover the molecular underpinnings of the disease. In...

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PMID: 26105539
DOI: 10.1038/nrc3961
PMCID: PMC4599785

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