Article

Scalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cells

2025-06-15

Abstract excerpt

Scalable generation of functionally mature hepatocytes from human pluripotent stem cells (hPSCs) is vital for regenerative medicine, disease modeling, and drug screening. We present a modular differentiation platform that enables serial expansion and cryopreservation of hepatic progenitors (hepatoblasts; HBs), supporting efficient downstream maturation. By modulating bile acid signaling with FGF19 and culturing un...

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Literature Corpus work: 320246a3-6be1-5246-bb90-ef551cf2d5fe
DOI: 10.1101/2025.06.13.659636

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