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Engineered Platforms for Maturing Pluripotent Stem Cell–Derived Liver Cells for Disease Modeling

1 Jan 2023

Abstract excerpt

Several liver diseases (eg, hepatitis B/C viruses, alcoholic/nonalcoholic fatty liver, malaria, monogenic diseases, and drug-induced liver injury) significantly impact global mortality and morbidity. Species-specific differences in liver functions limit the use of animals to fully elucidate/predict human outcomes; therefore, in vitro human liver models are used for basic and translational research to complement...

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PMID: 36738860
DOI: 10.1016/j.jcmgh.2023.01.013

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